International Journal of Environmental Science and Development

Abstract— Heart failure (HF) is a complex clinical syndrome that results from left ventricular myocardial dysfunction and contributes to dyspnea, fatigue and fluid retention. It's essential to characterize disease progression and symptoms to optimize therapy selection. Also, understanding the mechanisms of HF to guide therapy selection is of vital importance. This review focuses on the demonstrating mechanisms of HF and points out the possible pathways involved in the process. Drug therapies of HF with different effects on specific targets are analyzed. Finally, we conclude the features of the now going drugs and depict the future perspectives of drug therapy of HF, including potential new targets and new drug therapies.

Index Terms— Heart failure (HF), excitation-contraction coupling (E-C coupling), drug therapy.

Yifan Su is with the SUNY ESF, NY 13210 USA (e-mail: suyifan3@126.com).

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Cite: Yifan Su, " The Molecular Mechanism and Drug Therapy of Heart Failure ," International Journal of Environmental Science and Development vol. 11, no. 9, pp. 455-459, 2020.

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).